CHARACTERIZATION OF CYTOKINE PROFILE IN ACUTE AND EARLY PERIODS OF TRAUMATIC SPINAL CORD DISEASE 

Ulyanov Vladimir Yuryevich, Candidate of medical sciences, junior researcher, department of new technologies in vertebrology and neurosurgery, head of endoscopy unit, Saratov Research Institute of Traumatology and Orthopedics, v.u.ulyanov@gmail.com
Norkin Igor Alekseevich, Doctor of medical sciences, professor, director of Saratov Research Institute of Traumatology and Orthopedics, v.u.ulyanov@gmail.com
Shchukovsky Valery Vladimirovich, Doctor of medical sciences, professor, sub-department of emergency and anesthesiology and resuscitation care, Saratov State Medical University named after V. I. Razumovsky, v.u.ulyanov@gmail.com
Puchinyan Daniil Mironovich, Doctor of medical sciences, professor, deputy director for research, Saratov Research Institute of Traumatology and Orthopedics, v.u.ulyanov@gmail.com
Konyuchenko Elena Anatolyevna, Junior researcher, department of laboratory and functional diagnostics, Saratov Research Institute of Traumatology and Orthopedics, v.u.ulyanov@gmail.com

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Тhe nonspecific protective and adaptive change, taking place in the human organism during cerebrospinal trauma, leads to an emergence of a new metabolic condition which determines the generalization of an inflammatory reaction and concomitant immune disorders. The research objective is a study of pro-inflammatory and anti-inflammatory cytokines concentration dynamics in peripheral blood of patients in acute and early periods of a spinal cord traumatic disease. 15 practically healthy persons were investigated as a control group. The authors has investigated concentrations of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and anti-inflammatory ones (IL-4, IL-10) in blood serum by means of the solid-phase immu-noassay in dynamics on the 1st–4th, 7th, 14 th and 21 st days from the moment of sus-taining the injury. It has been revealed that acute and early periods of a spinal cord traumatic disease are characterized by the differences in a cytokine imbalance degree of manifestation.

traumatic disease, spinal cord, pro-inflammatory and anti-inflammatory cytokines.